![]() More recent nutritional research has focused on the antioxidant effects of functional foods containing high concentrations of phenolic compounds such as flavonoids and anthocyanins. However, vitamins C and E (independently or in combination with N-acetylcysteine, β-carotene, or α-lipoic acid) remain controversial due to conflicting reports of effectiveness with potential post-exercise pro-oxidant effects on muscle protein anabolism, endogenous antioxidant capacity, and mitochondrial biogenesis. The use of antioxidant supplements, such as vitamins C and E, in athletic applications to help fortify the body’s endogenous antioxidant response has spurred some success. Exercise-induced muscle soreness is indirectly related to inflammation as a product of high nociceptor and mechanoreceptor sensitivity to potent metabolites released during muscular degeneration. Ultimately, this increase facilitates excessive cell damage, altered cell signaling, decreased cellular performance, lipid peroxidation, oxidation of proteins and glutathione, and subsequent DNA damage. As a result, this type of long duration mechanical muscle stress and high oxidative metabolic demand, significantly increases free radical production beyond the capacity of the endogenous antioxidant systems. Over the 48-h recovery period, P changes in medial quadriceps soreness from pre-run measures were smaller compared to TC.Īcute bouts of strenuous aerobic exercise facilitate a stress response characterized by mechanical muscle damage, oxidative stress, and inflammation that parallels the physiological stress response associated with many adverse traumatic cardiovascular events and illnesses. Soreness perception between the groups was different over time in the medial quadriceps ( p = 0.035) with 34 % lower pre-run soreness in TC compared to P. ![]() Inflammatory markers were 47 % lower in TC compared to P over time ( p = 0.053) coupled with a significant difference between groups ( p = 0.017). ![]() Despite lower antioxidant activity pre-run in TC compared to P, changes from pre-run levels revealed a linear increase in antioxidant activity at 24 and 48-h of recovery in TC that was statistically different (16–39 %) from P and pre-run levels. Attenuations in TC muscle catabolic markers were reported over time for creatinine ( p = 0.047), urea/blood urea nitrogen ( p = 0.048), total protein ( p = 0.081), and cortisol ( p = 0.016) compared to P. Subjects in the TC group averaged 13 % faster half-marathon race finish times ( p = 0.001) and tended to have smaller deviations from predicted race pace ( p = 0.091) compared to P. ![]()
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![]() ![]() Father and son worked desperately to finish the map in time for publication: The finished map faithfully reproduced the contours, features and labels of his father's design, but omitted the route (with dates) taken by the Hobbits Frodo and Sam on their way to destroy the One Ring in Mount Doom. His son Christopher drew the contour map from the design. He made a detailed pencil, ink and coloured pencil design on graph paper, enlarged five times in length from the main map of Middle-earth. The paper became soft, torn and yellowed through intensive use, and a fold down the centre had to be mended using parcel tape. ![]() The map had many annotations in pencil and a range of different inks added over the years, the older ones faded until almost illegible. Tolkien worked for many years on the book, using a hand-drawn map of the whole of the north-west of Middle-earth on squared (not graph) paper, each 2cm square representing 100 miles. The maps are a large drawing of the north-west part of Middle-earth, showing mountains as if seen in three dimensions, and coasts with multiple waterlines a more detailed drawing of "A Part of the Shire" and a contour map by Christopher Tolkien of parts of Rohan, Gondor, and Mordor, very different in style. The Lord of the Rings contains three maps and over 600 placenames. The city of Minas Tirith (lower left) with its large encircling wall (the Rammas Echor) and the ruined city of Osgiliath astride the River Anduin nearby are shown. Tolkien's design for his son Christopher's contour map on graph paper with handwritten annotations, of parts of Gondor and Mordor and the route taken by the Hobbits with the One Ring, and dates along that route, for an enlarged map in The Return of the King Detail of finished contour map by Christopher Tolkien, drawn from his father's graph paper design. This line represented the printed delineation of the margin of the school paper, which came with the printed instruction "Do not write in this margin". Both maps have a heavy vertical line not far from the left-hand side, the one on the map of Wilderland marked "Edge of the Wild". The map is overprinted with placenames in red. Mirkwood is shown as a mixture of closely packed tree symbols, spiders and their webs, hills, lakes, and villages. The Misty Mountains are drawn in three dimensions. The other is a drawing of " Wilderland", from Rivendell in the west to the Lonely Mountain and Smaug the dragon in the east. The first is Thror's map, in the fiction handed down to Thorin, showing little but the Lonely Mountain drawn in outline with ridgelines and entrances, and parts of two rivers, decorated with a spider and its web, English labels and arrows, and two texts written in runes. In the view of the Tolkien critic Tom Shippey, the maps are largely decorative in the "Here be tygers" tradition, adding nothing to the story. ![]() The Hobbit contains two simple maps and only around 50 placenames. K-index Alerts are issued when the NOAA estimated Kp-indices reach 4, 5, 6, 7, 8, or 9.Further information: Tolkien's artwork and Geography of Middle-earth The Hobbit ![]() K-index Warnings are issued when NOAA estimated Kp-indices of 4, 5, 6, and 7 or greater are expected. Important magnetometer observations are also contributed by the Institut de Physique du Globe de Paris and the Korean Space Weather Center K-index Watches are issued when the highest predicted NOAA estimated Kp-indices for a day are K = 5, 6, 7, or >= 8 and is reported in terms of the NOAA G scale. Geological Survey, Natural Resources Canada (NRCAN), the British Geological Survey, the German Research Centre for Geosciences (GFZ), and Geoscience Australia. These data are made available thanks to the cooperative efforts between SWPC and data providers around the world, which currently includes the U.S. The Estimated 3-hour Planetary Kp-index is derived at the NOAA Space Weather Prediction Center using data from the following ground-based magnetometers: Sitka, Alaska Meanook, Canada Ottawa, Canada Fredericksburg, Virginia Hartland, UK Wingst, Germany Niemegk, Germany and Canberra, Australia. ![]() ![]() ![]() Criteria for Ranking the Top 10 Venture Capital Firms for Biotechnology The right VC partner can make all the difference between the success or failure of a biotech startup. They have a wealth of knowledge and experience that they can share with their portfolio companies, including technical expertise in drug development, clinical trials, and regulatory compliance, as well as operational and strategic guidance in all areas of business. VC firms bring more than just capital to the table. Venture capital firms are the ideal match for these types of startups, as the investment model allows for high-risk, long-term investments in innovative companies with the potential for substantial returns. Traditional sources of funding, such as banks and angel investors, may not be a good fit for biotech startups due to the high risk and long timelines inherent in the industry. One of the biggest hurdles for biotech entrepreneurs is obtaining funding to bring their ideas to realization. Understanding the Role of Venture Capital in Biotech Startups ![]() ![]() But, as with any industry, innovation requires funding, and this is where venture capital comes in. In the past few years, the industry has witnessed significant growth and innovation, with startups and established companies alike working on new approaches to treating and diagnosing diseases. Introduction: Exploring the Biotechnology Venture Capital Landscapeīiotechnology is a broad and diverse field, covering everything from developing new drugs and therapies to creating novel diagnostic tools and devices. In this article, we take a deep dive into the top 10 venture capital firms for biotechnology, providing insights into their investment strategies, key investment areas, and success stories. Identifying the right VC partner is vital for these budding entrepreneurs, as they need the financial support, expertise, and guidance to take their ideas from concept to market. As the biotechnology industry continues to flourish and gain momentum, venture capital firms are looking to invest in innovative startups that are developing transformative treatments and technologies. ![]() ![]() ![]() This download is valid for the product(s) listed below: Drivers Hard Disk Controller Silicon Image SiI 3124 SoftRaid 5 Controller Download. System manufacturer - System Product Name Silicon Image SiI 3124 SoftRaid 5 Controller download. Hewlett-Packard - HP Compaq dc7800 Convertible Minitower Based on a radically new chip architecture, the sii 3124 is a single-chip pci-x to 4-port serial ata sata host controller, that takes sata performance and features to enterprise levels. #SILICON IMAGE 3124 SOFTRAID 5 CONTROLLER SERIAL# System manufacturer - System Product Name (To Be (To Be Filled By O.E.M.- SKU:To Be Filled By O.E.M.) Silicon image sii 3124 softraid 5 controller drivers for windows 10 圆4. I bought the Silicon Image Sil 3132 controller and was happy to see that it was immediately seen by the motherboard and BIOS. ![]() ![]() The software drivers provided on this page are generic versions and can be used for general purposes. Unfortunately, while Windows 10 recognized the controller, found the driver for it and reported that the device works correctly, when I plug my external HDDs, Windows 10 starts to choke and become unusable. However, computer original equipment manufacturers (OEMs) may have altered the features, incorporated customizations, or made other changes to the software or software packaging they provide. To avoid any potential installation incompatibilities on your OEM system, We recommend that you check with your OEM and use the software provided via your system manufacturer. Download drivers for Silicon Image SiI 3124 SoftRaid 5 Controller. We or the computer original equipment manufacturer (OEM) may not provide technical support for some or all issues that could arise from the usage of this generic version of software drivers. #SILICON IMAGE 3124 SOFTRAID 5 CONTROLLER DRIVERS# To download the drivers, select the appropriate version of driver and. #SILICON IMAGE 3124 SOFTRAID 5 CONTROLLER DRIVERS#.#SILICON IMAGE 3124 SOFTRAID 5 CONTROLLER SERIAL#.Not sure if that's an issue, but there is no option to define a hard drive as any other type anyway. The only thing I notices is vmware player is trying to add the disks as IDE when these are SATA disks. Tried formatting the partition, same issue. I tried no partition on the disks or create a raw partition, same issue. I have tried starting VMWare Player as administrator, same issue. I have tried making the disks offline and online, same issue. The drives have nothing on them, so I always chose to use the whole disk. Cannot open the disk 'C:\Users\HP\Documents\Virtual Machines\Ubuntu\Ubuntu-1.vmdk' or one of the snapshot disks it depends on.". While I can add a physical drive through the VM Settings page, and I can see VMWare picks up the right drive and shows the right size, when I try to start the VM, I get this error I am trying to add the 4 disks to Ubuntu as raw physical disks, so I can play with Linux LVM features. The 4 drives show up as individual disks in Windows Disk Manager. The card shows up as Silicon Image SiL 3132 SoftRaid 5 Controller Chip Type SST 39VF020. I have 4 SATA drives in an external enclosure connected to the PC through eSATA to an eSATA card. I used the easy install option and Ubuntu installed by itself with no problem. Everything is a fresh install from today. The host is running Windows 7 Ultimate 64-bit Service Pack 1, VMware Player version 5.0.1 build-894247 which is the latest as of today, and the guest OS is Ubuntu 12.10 desktop 32bit. ![]() ![]() ![]() If drivers get held up in traffic, wait times get updated automatically, putting customers’ minds at ease. Google Maps dynamically plans new routes based on real-time traffic information, even helping you choose the most desirable lanes.Ĭreate a custom 'MyMap' for your favorite places near or far to share your local knowledge and tell a richer story.Įmpower your customers with accurate, up-to-date informationĭeliver great customer experiences with accurate wait times and routes that are optimized based on real-time traffic conditions. ![]() The selection of pre-prepared food is always good, normally having pasta, chicken, salads, and other. Travel smoothly, bid farewell to congestion Grocery 24 Hour Store locations in Columbus, OH. ![]() Fine navigation and lane guidance will escort you all the way. Publix: Hours will vary by location, with most stores closing between 7 p.m. You don’t have to worry about missing an illegible ramp exit any more. 24 hours a day, while others close at 8 p.m. The first step with right direction gets ahead of others in the following steps. This store is quite large, clean, with good parking and best of all it's 24/7, which makes it super. In August 2013, it was determined to be the world's most popular app for smartphones, with over 54% of global smartphone owners using it at least once. First of all, the hours are listed until midnight but they apparently stay open 24hrs. Google Maps for Android and iOS devices was released in September 2008 and features GPS turn-by-turn navigation along with dedicated parking assistance features. You can also allow the Google Maps app to access your Android and iPhone address books to quickly find saved addresses. All you need to do is to save your home and office addresses in Google Maps, and the system will automatically fill them in as you type, speeding up your search. ![]() ![]() ![]() This change, along with others, has caused issues for backup apps. Some backup apps aren’t yet compatible with Catalina: One of the big changes in Catalina is the way macOS runs from a read-only system volume that’s separate from the writeable data volume that stores your apps and documents.If you still need to download Mojave, Apple has a support document explaining how to get it. If you rely on 32-bit apps, you’ll need to upgrade them (which may be expensive), find alternatives (which may be pricey and comes with a learning curve), or run them in a virtual machine (see “ Moving to Catalina: Keep Your 32-Bit Mac Apps Running with Parallels,” 18 September 2019). Catalina won’t run 32-bit apps: No TidBITS readers should be surprised by this news at this point.Nevertheless, for most people, we recommend delaying your upgrade for a while for a variety of reasons: When that time comes, we strongly recommend that you follow the advice in Joe Kissell’s Take Control of Upgrading to Catalina. It’s better to do so proactively than reactively. Note that I say “when” and not “if” because something, such as the purchase of a new Mac, the need for updated software, or compatibility with iOS, will force you to upgrade at some point. Regardless of whether or not the release date is a historical coincidence, you’re now faced with the question of when to upgrade to Catalina. It certainly wasn’t a discovery-the island had been inhabited by the native Pimugnans since 7000 BCE. We’re dying to know if, as Michael Cohen pointed out in our TidBITS Slack group, Apple intentionally waited to release Catalina on the 477th anniversary of the Portuguese explorer Juan Rodríguez Cabrillo claiming Santa Catalina Island for Spain on 7 October 1542. For an overview of what’s new, see “ No Mac Is an Island with macOS Catalina” (3 June 2019). Catalina advertises itself as an 8.09 GB download in System Preferences > Software Update, but its App Store page claims that it’s only 4.9 GB. MacOS 10.15 Catalina Ships, Upgrade with CautionĪpple today released macOS 10.15 Catalina, leaving just iOS 13 for the HomePod and watchOS 6 for the Apple Watch Series 1 and Series 2 as vaporware. #1679: iOS 17’s Check In, iOS 17.03 addresses overheating, Mac browser popularity, Arc adds AI features, do you use Finder tags?.1680: iPhone recommendations for seniors, unsticking iCloud Drive sync, iOS bug turns off devices at night, iOS 16 security fixes.#1681: Take Control Books 20th anniversary, USB-C Apple Pencil, Kini motion detector monitors access, topical social spaces. ![]() #1682: Apple’s “Scary Fast” announcement, X.1 updates to 2023 OS versions, Microsoft Word’s 40th anniversary, 5G wireless Internet.#1683: New M3 chips in updated MacBook Pros and iMac, record Apple Q4 profits on lower revenues, no more 27-inch iMacs. ![]() ![]() ![]() It is completely absent in cereal grains. Taurine is found in fish, meat, and milk. Even when fed the same diet, large and giant breeds produce less taurine than small and toy breeds. These breeds have either a metabolic abnormality that impairs the taurine synthesis and utilization or they have naturally occurring higher taurine requirements. Those breeds include American Cocker Spaniels, Golden Retrievers, Labrador Retrievers, English Setters, Newfoundlands, Saint Bernards, Portuguese Water Dogs, Great Danes, Boxers, Irish Wolfhounds, and Doberman Pinschers.īig dogs are at higher risk of developing taurine deficiency when compared to small dogs, they have a much slower taurine production rate. While taurine is known to be an "essential" amino acid for cats, recent studies show it may be required in the diet for some dog breeds as well. ![]() Which Pets Are Most at Risk for Taurine Deficiency? (Today's chemistry lesson!) More accurately, in the presence of vitamin B6, the methionine is transformed into cysteine and then the cysteine is needed for producing taurine. Most dogs make taurine from other amino acids called cysteine and methionine via the cysteine sulfinic pathway using vitamin B-6, zinc and manganese as cofactors. Taurine is considered nonessential for dogs, but it is essential for cats, meaning cats have 11 essential amino acids. The other 10 amino acids are “essential,” meaning they must be supplied by the diet. In dogs, 12 amino acids are “nonessential,” meaning the body can make them on its own. Taurine helps to generate and regulate nerve impulses and supports the maintenance of normal fluid balance it is also used by the body in visual pathways, as well as in the brain and nervous system, where it works together with glycine and GABA as a neurotransmitter. It functions in tissues by stabilizing cell membranes and aiding the transport of potassium, sodium, calcium, and magnesium in and out of cells. It is found in high quantities in the brain, retina, heart, and in platelets. There are 22 amino acids that are needed for proper functioning of the body. Amino acids are the basic building blocks of protein. ![]() ![]() Spear & Jackson 600mm Metal Handle Leaf Rake (38) 12.95. Saxon Fibreglass Adjustable Metal Leaf Rake (8) 13.80. Use a garden leaf rake to collect loose leaves and other garden. Wolf Garten Multichange Mini Rake (0) 14.95. The Spear & Jackson Long Handled Leaf Grabbers work to limit the need for excessive bending. They are useful for moving rocks, or compost, or even relocating trees or large shrubs from one spot to another, as well as transporting bricks and disposing of debris. Saxon Fibreglass Long Handle Metal Head Leaf Rake (10) 19.99. They are tough yet lightweight, easy to work with and. Straining with a load is not necessary with our reliable and easy to pull trolleys.Īll green-fingered enthusiasts will require wheelbarrows as they are such great multi-purpose items. Make light work of collecting leaves, grass cuttings and other debris with these long handled grabs. These handy trolleys are perfect for all gardeners and their compact nature means they can be easily stored in sheds or garages. Our garden trolleys will help ease the burden of carrying pots and plants or moving waste. ![]() ![]() They are also useful for creating small holes for planting bulbs, annuals or perennials. Small handheld trowels are used for digging, smoothing or moving small amounts of soil or other material. It’s one of the most important implements in the range, and our products will ensure that your job is completed to a high standard. Gardeners will also require a sturdy garden fork to help them loosen, lift or turn over the soil. ![]() Hedge shears are essential if you want to remove woody material from the garden or trim shrubs to create more space and freshen up the look. Draper 82899 Tools LG/HD Leaf Grabber, Green with Grey Handles. These are essential horticultural implements for novice gardeners or keen and seasoned enthusiasts. AMES Leaf Grabber Rake with Long Handle & Cushioned Grip for Leaves, Lawn Clippings, Twigs, Yard Waste. Our garden rakes will ensure any leaves and debris can be cleared from the grass to keep it tidy. ![]() ![]() ![]() On the same day, 20-year-old junior engineer Xiang Kairan from Shenzhen is among a group that sits down to tea with Provincial Communications Administration officials and a local leader from the telecom company China Unicom. Briefly distracted, Chloe’s mum takes a photograph of her daughter and shares it to a chat group in Chinese-owned social media app WeChat. Her mother turns from her own PC and suggests-in Mandarin/Dialect hybrid-Chloe’s social time is up. Eliminated, exasperated, she posts an ironic emote parody on TikTok. Still in a semi ‘Rona Iso’ 10-year-old Australian Chloe Yingchao is playing Fortnite. What follows is a speculative, fictional story. Consciousness is another limit upon which total war will press, and when war has co-opted consciousness what will we do-or even be? Adverserial relations will thus multiple via biolocial processes of mutation, while digital war’s front lines will recede to reflevive, recursive interstices. Sovereignty will not just be defined in the ontology of mathematical alterity. From this black hole of Xenowar will pulse another type of Un-War, fought at the edges of the incomputable, an axiomatic reboot of Non-Turing mathematics and non-Abelian anyons of topological quantum computing. State and Stack firewalls will constitute cosmotechnic event horizons of compression. At other scales friction will spiral in recursions of homotopic functionalities across Stack infrastructures and diastereotopic data planes of invertible war: ‘recurgency’ will replace insurgency. Some Stacks may be enantiotopic to each other, mirror images but not superimposable. Equally, an inability to cut and paste borders of Stack topology will accentuate disconnection. Westphalian deformations will increase turbulence at higher manifolds and dimensions. Topological equivalence will mean the continuous mapping of States within Stack homeomorphism via oscillations of stretching and contraction. This deforms war’s properties while preserving its form: asymmetry will be expressed as inhuman scales, and feedback loops will redefine geopolitics. Simultaneously, the technological and biological merge, transforming conflict into three dimensions in a way that emphasises connection and shape, not geometry. ‘Users’ are a ‘standing reserve’ for the Gestell. Combatants emerge from corporations and nations as the understanding of war as human activity evolves into the realisation that all human activity is now war. War persists, but Clausewitz’s wunderliche Dreifaltigkeit morphs to become topological. Xenowar is the Clausewitzian trinity spun in recursive loops of alterity, where conflict diagonalizes into an inhuman, alien cognition. ‘Xeno’ because this war incorporates the alien and the Other into a new, dynamic, topological trinity. What has war become in an age of recursive computation and the globalised technobiome? Combining speculative fiction, Clausewitzian theory and metadisciplinary analysis, this exploratory piece outlines the emergence of a war that is both new and familiar-Xenowar. ![]() ![]() ![]() When all layers are deselected, the right panel shows these settings: Right panel properties with no selected layers The Code tab displays the code corresponding to your layers. Learn more about linked design in this section. You can also use the Linked Design option to include embed links to Lunacy layers directly into website code: when you update them in Lunacy, they’ll be automatically updated on your website. Shows the colors and fonts used in selected layers.Ĭlick on the Export tab to open up export settings for your entire project or click individual/multiple layers to export just them. Activate prototyping options and turn your static designs into interactive prototypes. Add effects (shadows, blurs) to your layers. Set the overall opacity of a layer and its blending mode.Įffects. The Style section displays the styles applied to your layer (text styles, color styles, effect styles, etc.) You can add styles from UI kits, create your own, and detach layers from applied styles. Create new component states, switch between them, and detach instances from main components. ![]() Rotate your layers and change their corner radius properties.Ĭomponent options. Controls vary depending on the selected layer. Use the buttons next to the position controls to flip your images and toggle the lock button on and off to preserve aspect ratio when resizing. Change the size of your layers and their position on the canvas. These properties are universal for almost all layer types: Right panel propertiesĪlignment and distribution controls appear when you select two or more layers. The set of controls and settings it displays depends on the type of the selected layer. The Design tab is the one you’ll interact with the most when working on your designs. There are three tabs at the top of the right panel: Design, Export, and Code. You’ll see a checkerboard pattern instead of a fill. You can also set the canvas color opacity to 0 so it becomes transparent. Press to reset the canvas to the default color. Use the Workspace color control in the right panel.Deselect all layers on the canvas and clear the Show pixel grid checkbox in the right panel.įind out about other zooming options.In the menu bar, select View → Pixel grid.When the zoom value exceeds 500, Lunacy displays a pixel grid. ![]() To zoom slower, additionally hold down Shift. The easiest way to zoom in and out in Lunacy is by holding down Ctrl / ⌘ and moving the mouse wheel. You can always use the scroll bars on the right and bottom of the workspace, but it’s not as convenient as the other options. To scroll horizontally, additionally hold down Shift.Īnother way to navigate the canvas is to hold down Space to activate the Hand tool and drag the canvas to wherever you need. If your design is taking up too much space on the canvas, use the mouse wheel to scroll vertically. Learn more about Lunacy’s features, interface capabilities, and useful tips and tricks to speed up your design process. An overview of Lunacy's basic features and capabilities ![]() |
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